Human Motion Driven Self-Powered Photodynamic System for Long-Term Autonomous Cancer Therapy
Zhuo Liu1,2, Lingling Xu1,3, Qiang Zheng1,3
1CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 100083, China.
ACS Nano
|June 20, 2020
Summary
This study introduces a self-powered photodynamic therapy (s-PDT) system that harvests energy from body motion. The innovative s-PDT system effectively inhibits tumor growth using two distinct light stimulation modes, offering a promising cancer treatment.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Long-term photodynamic therapy (PDT) for tumors needs a sustainable power source.
- Current battery or wireless charging methods for PDT devices are inconvenient.
- Telemedicine demands improved patient compliance and autonomous treatment management.
Purpose of the Study:
- To develop a self-powered photodynamic therapy (s-PDT) system for autonomous tumor treatment.
- To investigate two irradiation modes for enhanced therapeutic efficacy.
- To create a wearable/implantable device for long-term cancer therapy.
Main Methods:
- Fabrication of an s-PDT system using a twinning structured piezoelectric nanogenerator.
- Energy harvesting from body motion to power a light-emitting diode (LED).
- In vitro evaluation using pulsed light stimulation on tumor cells and in vivo testing in mice with transplanted tumors using intermittent continuous light stimulation.
Main Results:
- The s-PDT system significantly suppressed tumor cell growth in vitro with pulsed light.
- In vivo studies in mice showed significant antitumor effects with intermittent continuous light stimulation.
- An 87.46% tumor inhibition rate was achieved in mice over 12 days.
Conclusions:
- The developed s-PDT system offers a sustainable and autonomous solution for long-term cancer treatment.
- The dual-mode irradiation capability enhances therapeutic potential.
- This technology paves the way for self-controllable, wearable/implantable devices for clinical cancer therapy.
