The GCAG Haplotype of the CRHBP Gene May Decrease the Risk for Robbery Behavior Among the Han Chinese

Hypothalamic-pituitary-adrenocortical axis gene polymorphisms have been reported to affect aggressive behavior. Corticotropin releasing hormone binding protein (CRHBP) polymorphisms have been shown to contribute to the susceptibility to stress-related disorders, including aggressive behavior. However, no study has been conducted on the relationship between CRHBP polymorphisms and aggressive behavior risk in the Han Chinese population. A case-control study that comprised 194 male criminals and 303 healthy controls was carried out to investigate the genetic association between several CRHBP gene polymorphisms and aggressive behavior risk in the Hunan Han population. Genotyping was conducted by using the improved multiplex ligase detection reaction method for four CRHBP loci: rs10062367, rs32897, rs7718461, and rs7721799. The incidence of the rs32897C allele was significantly lower in the robbery group compared with the control subjects after a Bonferroni correction (p = 0.016), indicating a protective role for the C allele of rs32897. Interestingly, a haplotypic analysis that was stratified by robbery and intentional injury showed that the haplotype consisting of rs10062367G, rs32897C, rs7718461A, and rs7721799G (which includes the protective rs32897 C allele) was significantly associated with decreased robbery risk (odds ratio [OR] = 0.31, p = 0.0005), but not for intentional injury (OR = 0.82, p = 0.44). The haplotype consisting of rs10062367G, rs32897T, rs7718461A, and rs7721799G carrying the rs32897 T allele significantly increased the risk for robbery (OR = 1.47, p = 0.0213), but not for intentional injury (OR = 0.92, p = 0.64). The rs32897 alleles and the haplotypes containing the rs32897 alleles, including GCAG and GTAG, may be factors associated with committing robbery in the Hunan Han population, and could be used to provide clinical counseling with regard to aggressive behavior. However, further studies including multiple ethnicities are needed.