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A Review of AEG-1 Oncogene Regulating MicroRNA Expression in Colon Cancer Progression

Sarubala Malayaperumal1, Sushmitha Sriramulu1, Ganesan Jothimani1

  • 1Department of Medical Biotechnology, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute (CHRI), Chettinad Academy of Research and Education (CARE), Kelambakkam, Chennai 603103, Tamil Nadu, India.

Endocrine, Metabolic & Immune Disorders Drug Targets
|June 20, 2020
PubMed

Insights

MicroRNAs regulate genes, and their dysregulation links to cancer. Targeting Metadherin (AEG-1) and microRNAs offers potential therapeutic strategies for cancer by altering cell proliferation and apoptosis.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs are key regulators of gene expression, crucial in cellular processes.
  • Dysregulated microRNA expression is implicated in the progression of various cancers.
  • Metadherin (AEG-1), an oncogene overexpressed in cancers, drives cell proliferation and invasion.

Purpose of the Study:

  • To review studies investigating the interplay between microRNA expression and Metadherin (AEG-1) in cancer.
  • To explore how targeting AEG-1 and microRNAs can suppress carcinogenesis.
  • To understand the molecular mechanisms underlying AEG-1 and microRNA regulation in tumorigenesis.

Main Methods:

  • Review of existing literature on microRNA expression profiles.
  • Analysis of studies targeting Metadherin (AEG-1) and its effect on microRNAs.
  • Examination of research on AEG-1 as a direct or indirect microRNA target.

Main Results:

  • Alterations in microRNA expression profiles are observed in cancer.
  • Targeting AEG-1 can lead to the suppression of carcinogenesis.
  • Both AEG-1 and microRNA levels influence cell proliferation and apoptosis.

Conclusions:

  • The modulation of microRNA expression and AEG-1 levels impacts cellular functions critical to cancer.
  • AEG-1's interaction with microRNAs provides insights into cancer's molecular mechanisms.
  • Targeting the AEG-1/microRNA axis presents a promising avenue for novel cancer therapeutic strategies.
Keywords:
AEG-1/MTDH/LYRICColorectal cancerbiomarkermicroRNAoncogene

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