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Updated: Dec 18, 2025

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
Published on: March 15, 2019
Effect of practical hyperoxic high-intensity interval training on exercise performance
Michihiro Kon1, Kohei Nakagaki2, Yoshiko Ebi3
1School of International Liberal Studies, Chukyo University, 101-2 Yagotohonmachi, Showa-ku, Nagoya, 466-8666, Japan; Department of Sports Sciences, Japan Institute of Sports Sciences, 3-15-1 Nishigaoka, Kita-ku, Tokyo, 115-0056, Japan.
Hyperoxic high-intensity interval training (HIIT) significantly improved both aerobic capacity and anaerobic performance in athletes. Normoxic HIIT also enhanced aerobic capacity, but to a lesser extent than hyperoxic training.
Area of Science:
- Exercise Physiology
- Sports Science
Background:
- High-intensity interval training (HIIT) is a popular training method.
- The role of hyperoxia in enhancing HIIT adaptations requires further investigation.
Purpose of the Study:
- To investigate the effects of a practical hyperoxic HIIT (HHIIT) protocol on aerobic and anaerobic exercise capacity in male athletes.
Main Methods:
- Sixteen male athletes were randomized into normoxic HIIT (NHIIT) or HHIIT groups.
- Both groups trained twice weekly for three weeks using a cycle ergometer protocol until exhaustion.
- Physiological assessments included maximal graded exercise, submaximal exercise, and 90-s maximal exercise tests before and after training.
Main Results:
- Maximal oxygen uptake increased significantly in both NHIIT and HHIIT groups.
- The HHIIT group showed significant improvements in blood lactate curve during submaximal exercise and mean power output during maximal exercise.
- Normoxic HIIT did not yield significant improvements in these anaerobic parameters.
Conclusions:
- A practical HHIIT protocol may be effective in enhancing both aerobic capacity and anaerobic performance.
- Hyperoxia during HIIT may provide additional benefits for anaerobic adaptations compared to normoxic conditions.
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