Related Experiment Video
Updated: Dec 18, 2025

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo
Published on: March 26, 2019
COVID-19 Neurologic Complication with CNS Vasculitis-Like Pattern
R Hanafi1,2, P-A Roger2, B Perin2
1From the Department of Neuroradiology (R.H., G.K., J.-P.P., O.O.), University Hospital of Lille, Hôpital Roger Salengro, Lille, France riyad.hanafi@chru-lille.fr.
This study details a unique neurological complication of COVID-19, involving extensive cerebral small-vessel ischemic lesions and skin rash. The findings support the "endotheliitis" mechanism in SARS-CoV-2 infections.
Area of Science:
- Neurology
- Infectious Diseases
- Vascular Biology
Background:
- Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, primarily presents as a respiratory illness.
- While uncommon, neurological manifestations of COVID-19 have been reported, including encephalopathy, stroke, and polyneuropathy.
- Cerebral small-vessel disease is a recognized complication of various systemic conditions.
Related Concept Videos
Cranial and Spinal Meninges
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
Disorders of the Nervous Tissue
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Vascular Spasm
Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
Cerebrospinal Fluid
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain....

