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COVID-19: therapeutic approaches description and discussion

Guilherme G Trindade1, Samyra M C Caxito2,3, Alessandra Rejane E O Xavier4

  • 1University of Brasília, Laboratory of Clinical Microbiology and Immunology, Campus Darcy Ribeiro, Asa Norte, 70910-900 Brasília, DF, Brazil.

Anais Da Academia Brasileira De Ciencias
|June 20, 2020
PubMed

Insights

The global response to COVID-19 has been unprecedented. While research into antiviral and antiparasitic drugs for Coronavirus is ongoing, non-pharmacological strategies remain the most effective treatment currently available.

Area of Science:

  • Public Health
  • Infectious Diseases
  • Virology

Background:

  • The emergence of COVID-19 (Coronavirus disease 2019) in December 2019 marked a significant global health crisis, comparable to the 1918 Spanish flu pandemic.
  • The SARS-CoV-2 virus has caused widespread public health disruption and economic instability worldwide.
  • Intensive global research efforts are focused on identifying effective treatments for COVID-19.

Purpose of the Study:

  • To compile and critically discuss existing data on therapeutic approaches for COVID-19.
  • To evaluate the potential of repurposed drugs as treatments for SARS-CoV-2 infection.
  • To assess the current landscape of COVID-19 treatment strategies.

Main Methods:

  • Literature review and data compilation of published studies on COVID-19 treatments.
  • Analysis of preliminary data from clinical trials investigating various therapeutic agents.
  • Discussion of both pharmacological (antivirals, antiparasitics) and non-pharmacological interventions.

Main Results:

  • Preliminary data suggests potential efficacy for certain antiviral and antiparasitic drugs against SARS-CoV-2.
  • However, the effectiveness of these pharmacological agents requires confirmation through rigorous clinical studies.
  • Non-pharmacological interventions have demonstrated significant efficiency as a primary strategy to date.

Conclusions:

  • Repurposed drugs show promise but need further clinical validation for COVID-19 treatment.
  • Non-pharmacological measures are currently the most effective approach for managing the pandemic.
  • Continued research is essential to establish definitive pharmacological treatments for Coronavirus disease.

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