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A glance upon Epigenetic and COVID-19
NatÁlia L DE Freitas1, Pedro Ricardo G Azevedo1, Fabiana BrandÃo1,2
1University of Brasília, Department of Pharmacy, Laboratory of Clinical Microbiology and Immunology, Campus Darcy Ribeiro, Asa Norte, 70910-900 Brasília, DF, Brazil.
Epigenetics influences SARS-CoV-2 infection outcomes and immune response. Targeting epigenetic modifications with epidrugs may offer novel COVID-19 therapeutic strategies.
Area of Science:
- Molecular Biology
- Immunology
- Virology
Background:
- Epigenetic modifications play a crucial role in regulating gene expression and immune system adaptation during pathogen-host interactions.
- SARS-CoV-2 infection pathophysiology is influenced by epigenetic alterations.
- Individuals with Lupus exhibit increased ACE2 receptor expression due to DNA methylation deregulation, making them susceptible to SARS-CoV-2.
Discussion:
- The interplay between epigenetic marks and immune adaptation determines the outcome of SARS-CoV-2 infection.
- DNA methylation deregulation is linked to increased ACE2 receptor expression in Lupus patients, enhancing SARS-CoV-2 infectivity.
- Epigenetic modifiers, or epidrugs, are emerging as potential therapeutic agents.
Key Insights:
- Epigenetics is integral to understanding SARS-CoV-2 infection dynamics.
- Lupus patients' susceptibility to SARS-CoV-2 is associated with epigenetic dysregulation.
- Epidrugs represent a promising avenue for COVID-19 treatment development.
Outlook:
- Further investigation into epigenetic mechanisms in COVID-19 is warranted.
- Targeting epigenetic pathways could lead to innovative therapeutic strategies for SARS-CoV-2.
- Exploring epidrugs for COVID-19 treatment holds significant potential.
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