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The Function and Mechanism of Enterovirus 71 (EV71) 3C Protease
Weihui Wen1, Zixuan Qi2, Jing Wang3
1Department of Microbiology, School of Medicine, Nanchang University, Nanchang, Jiangxi, People's Republic of China.
Current Microbiology
|June 20, 2020
Summary
Enterovirus 71 (EV71) causes hand, foot, and mouth disease. Understanding EV71 3C protease is crucial for developing antiviral drugs to combat viral replication and immune system inhibition.
Area of Science:
- Virology
- Molecular Biology
- Infectious Diseases
Background:
- Enterovirus 71 (EV71) is a primary cause of hand, foot, and mouth disease, prevalent globally, especially in the Asia-Pacific region.
- EV71 was first identified in 1969 from infants with central nervous system diseases.
Purpose of the Study:
- To review the structure, function, and mechanism of the EV71 3C protease.
- To highlight the importance of EV71 3C protease in viral replication and pathogenesis.
- To emphasize the need for antiviral drugs targeting EV71 3C protease.
Main Methods:
- Literature review focusing on EV71 3C protease.
- Analysis of the structural and functional properties of EV71 3C protease.
- Examination of the role of EV71 3C protease in viral replication and host immune response.
Main Results:
- EV71 3C protease is a cysteine protease essential for cleaving viral and host proteins.
- The protease facilitates viral replication by processing viral polyproteins and affecting host proteins.
- EV71 3C protease contributes to pathogenesis by inhibiting the innate immune system and inducing apoptosis.
Conclusions:
- EV71 3C protease is a critical factor in EV71 pathogenesis.
- Targeting EV71 3C protease is a promising strategy for developing novel antiviral therapies.
- Further research into EV71 3C protease structure and function can guide drug development.
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