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Gleich syndrome: a systematic review.

Roger Haber¹, Joanna A Chebl², Maria El Gemayel³

¹Dermatology Department, Faculty of Medicine, Balamand University, Saint Georges Hospital UMC, Beirut, Lebanon.

International Journal of Dermatology

|June 20, 2020

Summary

Gleich syndrome, a rare disorder causing hypereosinophilia and angioedema, presents with symptoms like fever and urticaria. Systemic corticosteroids are effective treatments, though further research into its pathophysiology is needed.

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Area of Science:

Rare autoimmune disorders
Clinical immunology
Dermatology

Background:

Gleich syndrome is a rare disorder characterized by hypereosinophilia and angioedema.
Clinical and therapeutic findings remain unclear, with symptoms including elevated IgM, weight gain, fever, and urticaria.

Purpose of the Study:

To review Gleich syndrome, assessing its clinical features, epidemiology, and treatment options.
To consolidate current knowledge on this rare hypereosinophilic entity.

Main Methods:

A systematic review of 32 articles, including case reports and series, focusing on eosinophilic angioedema and Gleich syndrome.
Data extraction included patient demographics, clinical and biological manifestations, and treatment protocols.

Main Results:

Common clinical findings include recurrent angioedema, fever, urticaria, weight gain, blood eosinophilia, and elevated immunoglobulin levels.
Corticosteroid therapy is identified as the primary treatment modality.

Conclusions:

Gleich syndrome is a distinct hypereosinophilic condition with a generally benign course.
The syndrome shows a favorable response to systemic corticosteroids, but further research is required to elucidate its pathophysiology and optimize therapeutic strategies.