Lysosome AKT Targeting in Metastatic Cancer

Metastatic cancer is caused by hyperactivated lysosomes. Such activation causes a fungus, Aspergillus fumigatus, to permanently activate the AKT gene network that controls the lysosome through positive feedback loops. Targeting such a network by the redox balance change, and with an antifungal medication eliminates the metastatic phenotype, the complexity and robustness of the cancer. This principal mechanism of gene targeting, which suppressed metastasis of unknown origin, was observed clinically.