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Updated: Dec 9, 2025

Live-Cell Förster Resonance Energy Transfer Imaging of Metabolically Regulated Akt Activation Dynamics in HepG2 Cells
Published on: May 23, 2025
Laser Disrupts AKT Hydrogen Network in Cancer
1Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA.
Abstract:
The cancer metastatic process is supported by the strong AKT hydrogen bond network. This network is formed by positive feedback loops generated in the cancer hypoxic microenvironment through the genomic AKT signaling locus. Laser paired photons disrupt the hydrogen network of the AKT active site by laser catalyzed fusion inducing the disappearance of the malignant phenotype. Paired photons increase photon density and energy at the target, inducing fusion of the AKT hydrogen network in cancer. Thus, targeting the network of the AKT active site by paired photons laser guided electrons catalyzes fusion and dismantles the hydrogen bond network, causing conversion of hydrogen into deuterium or helium. This results in the disappearance of cancer complexity, robustness, and malignant phenotype, leading to cancer cell apoptosis and effective clinical applications.
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