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Ocular dimensions following cryotherapy for active stage of retinopathy of prematurity
J Teller1, I Nissenkorn, I Ben-Sira
1Maurice and Gabriela Goldschleger Eye Institute, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Insights
Cryopexy treatment for active retinopathy of prematurity (ROP) in premature children did not significantly alter central corneal thickness, anterior chamber depth, or axial length compared to untreated eyes. Axial length correlated with myopia degree.
Area of Science:
- Ophthalmology
- Pediatric Ophthalmology
- Retinopathy of Prematurity Research
Background:
- Retinopathy of prematurity (ROP) is a leading cause of visual impairment in premature infants.
- Cryopexy is a treatment modality for active ROP, but its long-term effects on ocular biometry are not fully understood.
- Understanding these effects is crucial for managing visual development in treated children.
Purpose of the Study:
- To compare ocular biometric parameters between cryopexy-treated and untreated eyes in children with a history of active retinopathy of prematurity.
- To investigate the relationship between axial length and myopia in this cohort.
Main Methods:
- Comparative biometric measurements (central corneal thickness, anterior chamber depth, axial length) were performed in 21 children.
- Eyes with prior stage 4 active ROP treated with cryopexy (n=26) were compared to untreated fellow eyes with stage 2 active ROP (n=15).
- Statistical analysis was used to compare parameters and assess correlations.
Main Results:
- No statistically significant differences were found in central corneal thickness, anterior chamber depth, or axial length between cryopexy-treated and untreated eyes.
- A significant correlation was observed between axial length and the degree of myopia in the studied children.
Conclusions:
- Cryopexy treatment for active retinopathy of prematurity does not appear to cause significant long-term changes in key ocular biometric parameters.
- Axial length remains a significant factor associated with myopia development in children with a history of ROP, regardless of cryopexy treatment.
Abstract:
In a group of 21 premature children in which 4 to 10 years earlier 26 eyes with stage 4 of active retinopathy of prematurity (ROP) were treated by cryopexy on the avascular retina, and 15 fellow eyes with stage 2 of active ROP were not treated, comparative measurements of the central corneal thickness, anterior chamber depth and eye axial length were performed. Not significant statistical differences of these parameters were found between the cryotreated and untreated eyes. The axial length was correlated with the degree of myopia.