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Related Experiment Video

Updated: Dec 18, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
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SuPAR, a potential inflammatory mediator in psoriasis pathogenesis.

Lamiaa Hamie1, Edward Eid1, Ossama Abbas1

  • 1Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.

Clinical and Experimental Pharmacology & Physiology
|June 20, 2020
PubMed
Summary

Soluble urokinase plasminogen activator receptor (suPAR) may play a role in psoriasis. Reduced uPAR staining in psoriatic skin suggests a potential link, though blood levels did not significantly differ in mild cases.

Keywords:
biomarkerepidermispsoriasissoluble urokinase plasminogen activator receptor (suPAR)

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Area of Science:

  • Dermatology
  • Inflammation Biology
  • Molecular Biomarkers

Background:

  • Psoriasis is an inflammatory skin condition linked to metabolic syndrome.
  • Current diagnostic and prognostic methods for psoriasis are insufficient.
  • Accurate molecular biomarkers are needed for psoriasis prognostication and treatment.

Purpose of the Study:

  • To investigate the role of soluble urokinase plasminogen activator receptor (suPAR) in psoriasis pathogenesis.
  • To assess the association between suPAR levels, psoriasis severity, and inflammatory markers (insulin, ESR, CRP).
  • To compare uPAR skin staining patterns in psoriatic versus healthy skin.

Main Methods:

  • Inclusion of 39 psoriasis patients and 30 healthy controls.
  • Collection of skin biopsies (affected/unaffected) and blood samples.
  • Analysis of uPAR skin staining, and blood levels of suPAR, ESR, CRP, and fasting insulin.

Main Results:

  • uPAR staining was prominent in unaffected skin of both psoriasis patients and controls, but weak/absent in psoriatic skin.
  • No significant elevation in CRP, ESR, or suPAR levels was observed in the mild psoriasis group compared to controls.
  • These findings suggest a potential role for epidermal uPAR loss in psoriasis pathogenesis.

Conclusions:

  • The loss of epidermal uPAR may be tentatively linked to psoriasis pathogenesis.
  • Mild-to-moderate psoriasis patients might not exhibit the strong association with metabolic syndrome seen in more severe cases.
  • Further research with larger cohorts is required to validate these findings.