Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

500
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
500
Mitochondria01:37

Mitochondria

19.2K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
19.2K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.1K
Bone Disorders01:29

Bone Disorders

5.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.0K
Replicative Cell Senescence02:15

Replicative Cell Senescence

4.2K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

No clear benefit of patient-specific instruments over conventional instrumentation in unicompartmental knee arthroplasty: A secondary analysis of a multicentre randomised trial with 5-year follow-up.

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA·2026
Same author

Longitudinal and cross-sectional evidence that daily resting and activity energy expenditures are independent in humans.

The Journal of physiology·2026
Same author

Self-selected dietary intake and association with achieved caloric restriction in CALERIE<sup>™</sup> 2.

Critical reviews in food science and nutrition·2026
Same author

The impact of maternal metabolic flexibility during gestation on infant adiposity in individuals with obesity.

American journal of physiology. Endocrinology and metabolism·2026
Same author

Skeletal muscle mitochondrial bioenergetics in pregnancy: a comparison of in vivo and in vitro outcomes.

Journal of the Endocrine Society·2026
Same author

Disseminating and Implementing the Science of Pediatric Obesity Treatment and Prevention.

Obesity (Silver Spring, Md.)·2026

Related Experiment Video

Updated: Dec 18, 2025

Solid Plate-based Dietary Restriction in Caenorhabditis elegans
06:13

Solid Plate-based Dietary Restriction in Caenorhabditis elegans

Published on: May 28, 2011

17.0K

Calorie Restriction and Aging in Humans.

Emily W Flanagan1, Jasper Most2, Jacob T Mey1

  • 1Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA;

Annual Review of Nutrition
|June 20, 2020
PubMed
Summary

Calorie restriction (CR) may extend lifespan and improve health by slowing aging processes. This review covers CR

Keywords:
CALERIEagingcalorie restrictionintermittent fastingmetabolic adaptation

More Related Videos

Measuring Caenorhabditis elegans Life Span on Solid Media
12:49

Measuring Caenorhabditis elegans Life Span on Solid Media

Published on: May 12, 2009

30.7K
Measurement of Survival Time in Brachionus Rotifers: Synchronization of Maternal Conditions
05:18

Measurement of Survival Time in Brachionus Rotifers: Synchronization of Maternal Conditions

Published on: July 22, 2016

8.7K

Related Experiment Videos

Last Updated: Dec 18, 2025

Solid Plate-based Dietary Restriction in Caenorhabditis elegans
06:13

Solid Plate-based Dietary Restriction in Caenorhabditis elegans

Published on: May 28, 2011

17.0K
Measuring Caenorhabditis elegans Life Span on Solid Media
12:49

Measuring Caenorhabditis elegans Life Span on Solid Media

Published on: May 12, 2009

30.7K
Measurement of Survival Time in Brachionus Rotifers: Synchronization of Maternal Conditions
05:18

Measurement of Survival Time in Brachionus Rotifers: Synchronization of Maternal Conditions

Published on: July 22, 2016

8.7K

Area of Science:

  • Gerontology and Nutritional Science
  • Cellular and Metabolic Adaptations
  • Aging Research

Background:

  • Calorie restriction (CR) is the sole nutritional intervention shown to potentially attenuate aging.
  • Evidence suggests CR can increase lifespan by 1-5 years, enhancing health span and quality of life.
  • CR influences intrinsic aging processes, improving metabolic health and reducing cardiometabolic disease risk.

Purpose of the Study:

  • To review CR's efficacy in modifying primary and secondary aging.
  • To outline implementation considerations for special populations.
  • To explore alternative interventions with comparable effectiveness and fewer side effects.

Main Methods:

  • Literature review of observational, preclinical, and clinical trials on calorie restriction.
  • Analysis of studies examining CR's impact on aging biomarkers and health outcomes.
  • Synthesis of research on alternative aging interventions.

Main Results:

  • CR demonstrates potential to increase lifespan and improve health span.
  • Cellular and metabolic adaptations are key mechanisms through which CR acts.
  • Implementation challenges exist, particularly for elderly and specific populations.

Conclusions:

  • Calorie restriction offers a promising strategy for aging attenuation and health improvement.
  • Further research is needed on CR's application in diverse populations and on alternative approaches.
  • Future directions include optimizing CR and exploring novel interventions for healthy aging.