Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurulation01:30

Neurulation

44.7K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
44.7K
Gastrulation01:56

Gastrulation

64.9K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
64.9K
Embryonic Connective Tissues01:20

Embryonic Connective Tissues

6.2K
During early development, the embryo forms two types of connective tissues— the mesenchyme and mucoid connective tissue.
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development.
6.2K
Development of the Lymphatic System01:15

Development of the Lymphatic System

1.8K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
1.8K
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

3.2K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.2K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

5.3K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-cell ultra-high-throughput multiplexed chromatin accessibility and gene expression sequencing (SUM-seq).

Nature protocols·2026
Same author

Discovery of a pre-vein progenitor that requires VEGF/ERK inhibition to complete vein differentiation.

bioRxiv : the preprint server for biology·2025
Same author

Inflammatory stromal and T cells mediate human bone marrow niche remodeling in clonal hematopoiesis and myelodysplasia.

Nature communications·2025
Same author

The pericardium forms as a distinct structure during heart formation.

Nature communications·2025
Same author

Genetic context of transgene insertion can influence neurodevelopment in zebrafish.

Genetics·2025
Same author

Single-cell ultra-high-throughput multiplexed chromatin and RNA profiling reveals gene regulatory dynamics.

Nature methods·2025
Same journal

PBX-dependent and -independent Hox programs establish and maintain motor neuron terminal identity.

Development (Cambridge, England)·2026
Same journal

NUDT21 regulates 3'UTR dynamics in epididymal principal cells to preserve sperm integrity.

Development (Cambridge, England)·2026
Same journal

Cell size control emerges from the vein-dependent coordinated divisions of distinct cell groups in Drosophila wing.

Development (Cambridge, England)·2026
Same journal

The people behind the papers - Kaoru Sugimura.

Development (Cambridge, England)·2026
Same journal

The people behind the papers - Zhainib Amir-Ugokwe and Kristy Red-Horse.

Development (Cambridge, England)·2026
Same journal

In preprints: toward a holistic lineage-tracing map of mammalian embryogenesis.

Development (Cambridge, England)·2026
See all related articles

Related Experiment Video

Updated: Dec 17, 2025

Three and Four-Dimensional Visualization and Analysis Approaches to Study Vertebrate Axial Elongation and Segmentation
12:59

Three and Four-Dimensional Visualization and Analysis Approaches to Study Vertebrate Axial Elongation and Segmentation

Published on: February 28, 2021

4.0K

The lateral plate mesoderm.

Karin D Prummel1,2, Susan Nieuwenhuize1,2, Christian Mosimann3,2

  • 1University of Colorado School of Medicine, Anschutz Medical Campus, Department of Pediatrics, Section of Developmental Biology, 12801 E 17th Avenue, Aurora, CO 80045, USA.

Development (Cambridge, England)
|June 21, 2020
PubMed
Summary
This summary is machine-generated.

The lateral plate mesoderm (LPM) is crucial for forming the heart, blood, and limbs in vertebrate embryos. This study clarifies LPM development, cell fates, and evolutionary origins, despite its complexity.

Keywords:
Cardiovascular systemCell fateDevelopmentEvolutionGene regulationLateral plate mesoderm

More Related Videos

Dissection and Lateral Mounting of Zebrafish Embryos: Analysis of Spinal Cord Development
05:36

Dissection and Lateral Mounting of Zebrafish Embryos: Analysis of Spinal Cord Development

Published on: February 28, 2014

14.2K
Stem cell-like Xenopus Embryonic Explants to Study Early Neural Developmental Features In Vitro and In Vivo
11:13

Stem cell-like Xenopus Embryonic Explants to Study Early Neural Developmental Features In Vitro and In Vivo

Published on: February 2, 2016

8.3K

Related Experiment Videos

Last Updated: Dec 17, 2025

Three and Four-Dimensional Visualization and Analysis Approaches to Study Vertebrate Axial Elongation and Segmentation
12:59

Three and Four-Dimensional Visualization and Analysis Approaches to Study Vertebrate Axial Elongation and Segmentation

Published on: February 28, 2021

4.0K
Dissection and Lateral Mounting of Zebrafish Embryos: Analysis of Spinal Cord Development
05:36

Dissection and Lateral Mounting of Zebrafish Embryos: Analysis of Spinal Cord Development

Published on: February 28, 2014

14.2K
Stem cell-like Xenopus Embryonic Explants to Study Early Neural Developmental Features In Vitro and In Vivo
11:13

Stem cell-like Xenopus Embryonic Explants to Study Early Neural Developmental Features In Vitro and In Vivo

Published on: February 2, 2016

8.3K

Area of Science:

  • Developmental biology
  • Evolutionary developmental biology
  • Embryology

Background:

  • The lateral plate mesoderm (LPM) is a critical embryonic tissue.
  • LPM gives rise to the heart, cardiovascular system, blood, kidneys, smooth muscle, and limb skeleton.
  • LPM is complex and lacks a clear genetic definition, making it difficult to study.

Purpose of the Study:

  • To outline the processes governing LPM specification and organization.
  • To describe LPM cell fates and their evolutionary trajectories.
  • To discuss the shared LPM origin of diverse organ systems.

Main Methods:

  • Literature review and synthesis of existing research on LPM development.
  • Analysis of genetic and molecular mechanisms underlying LPM formation.
  • Comparative embryology to infer evolutionary pathways.

Main Results:

  • Detailed description of LPM specification and patterning.
  • Identification of key cell populations and their developmental potentials within the LPM.
  • Reconstruction of evolutionary histories for LPM-derived structures.

Conclusions:

  • Understanding LPM development is key to comprehending vertebrate organogenesis.
  • The LPM serves as a model for studying the evolution of complex organ systems.
  • Further research into LPM genetics can illuminate developmental processes and evolutionary links.