Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

157
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
157
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

314
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
314
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

200
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
200
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

320
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
320
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

131
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
131
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

172
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
172

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Association Between SARS-CoV-2 Exposure, COVID-19 Vaccination and Psoriatic Arthritis-A Nested Case-Control Study.

Vaccines·2026
Same author

Semaphorin3A Rewires CD4<sup>+</sup> T-Cell Metabolism via AKT/mTORC1 Inhibition in Health and Rheumatoid Arthritis.

International journal of molecular sciences·2025
Same author

Patient characteristics, disease manifestations and diagnostic findings of consecutive patients suspected of Giant Cell Arteritis (GCA) - retrospective experience from a fast-track clinic in Israel.

Clinical rheumatology·2025
Same author

Neurosarcoidosis Masquerading as Spinal Stenosis.

Diagnostics (Basel, Switzerland)·2024
Same author

Tofacitinib Regulates Endostatin via Effects on CD147 and Cathepsin S.

International journal of molecular sciences·2024
Same author

COVID-19 Vaccine Effectiveness among Patients with Psoriatic Disease: A Population-Based Study.

Vaccines·2024

Related Experiment Video

Updated: Dec 17, 2025

Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain
07:19

Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Published on: March 24, 2023

5.7K

Polymyalgia Rheumatica: a Common Disease in Seniors.

Tal Gazitt1,2, Devy Zisman3,4, Gregory Gardner5

  • 1Division of Rheumatology, University of Washington, Seattle, USA. tgazitt@gmail.com.

Current Rheumatology Reports
|June 21, 2020
PubMed
Summary
This summary is machine-generated.

Polymyalgia rheumatica (PMR) is a common inflammatory condition in older adults. Current treatments have limitations, necessitating research into new therapeutic strategies and improved monitoring for this condition.

Keywords:
EORAGCAICI-related PMRPMRRS3PE

More Related Videos

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

686
Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass
07:44

Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass

Published on: July 14, 2023

1.5K

Related Experiment Videos

Last Updated: Dec 17, 2025

Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain
07:19

Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Published on: March 24, 2023

5.7K
Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

686
Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass
07:44

Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass

Published on: July 14, 2023

1.5K

Area of Science:

  • Rheumatology
  • Immunology
  • Geriatrics

Background:

  • Polymyalgia rheumatica (PMR) is a prevalent inflammatory condition in individuals over 50.
  • Characterized by proximal pain and stiffness, PMR can be mimicked by other disorders like giant cell arteritis (GCA).
  • Current treatments, primarily glucocorticosteroids (GC), have variable efficacy and significant toxicity in older adults.

Purpose of the Study:

  • To review the latest findings in polymyalgia rheumatica (PMR).
  • To cover etiologic factors, genetic associations, diagnostic methods, and treatment advancements.
  • To highlight the need for novel therapeutic strategies due to limitations of current GC-based regimens.

Main Methods:

  • Literature review of recent findings in PMR.
  • Analysis of advancements in diagnostic and monitoring tools.
  • Exploration of emerging therapeutic targets and strategies.

Main Results:

  • PMR shares pathophysiological links with GCA, driving new research.
  • Novel therapeutic targets, including IL-6 blocking agents, are under investigation.
  • Current treatments pose significant morbidity risks, emphasizing the need for alternatives.

Conclusions:

  • Understanding PMR pathophysiology is advancing treatment options.
  • New immunopathologic targets offer promise for future PMR therapies.
  • Developing safer and more effective treatments for PMR is crucial for improving patient outcomes.