Related Experiment Video
Updated: Apr 28, 2026
02:28
Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
Published on: March 1, 2024
1.1K
The Association Between SARS-CoV-2 Exposure, COVID-19 Vaccination and Psoriatic Arthritis-A Nested Case-Control
Amir Haddad1,2, Ella Zabari Parnis1, Nili Stein3
1Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3109601, Israel.
Vaccines
|April 27, 2026
Summary
This study found no significant link between COVID-19 infection or vaccination and developing Psoriatic Arthritis (PsA). Further research may be needed to rule out small associations with PsA development.
Area of Science:
- Immunology
- Rheumatology
- Epidemiology
Background:
- The COVID-19 pandemic has raised concerns about its effects on immune-mediated diseases.
- Understanding potential links between SARS-CoV-2 and Psoriatic Arthritis (PsA) is crucial.
Purpose of the Study:
- To investigate the association between SARS-CoV-2 infection and COVID-19 vaccination with the development of Psoriatic Arthritis (PsA).
Main Methods:
- A retrospective nested case-control study involving over 3 million adults.
- Matched 718 PsA patients with 7180 controls based on age and sex.
- Analyzed SARS-CoV-2 exposure and COVID-19 vaccination status within six months prior to PsA diagnosis, adjusting for confounders.
Main Results:
- No statistically significant association was found between SARS-CoV-2 infection and PsA development (OR=1.08, p=0.652).
- COVID-19 vaccination was also not significantly associated with PsA development (OR=1.10, p=0.45).
- Observed differences in SARS-CoV-2 exposure between cases and controls were not statistically significant (p=0.115).
Conclusions:
- This study found no statistically significant association between SARS-CoV-2 exposure or COVID-19 vaccination and PsA development within six months.
- While no significant link was identified, small differences cannot be definitively excluded.
More Related Videos
Related Concept Videos
01:11Genome-wide Association Studies-GWAS
12.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
12.4K
01:03Rous Sarcoma Virus (RSV) and Cancer
5.2K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.2K
01:03Rous Sarcoma Virus (RSV) and Cancer
4.9K
4.9K
01:05Single Nucleotide Polymorphisms-SNPs
14.4K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
14.4K
01:29Bias in Epidemiological Studies
1.6K
Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:
1.6K
01:20The JAK-STAT Signaling Pathway
10.1K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
10.1K