Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

246
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
246
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

204
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
204
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

350
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
350
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

1.4K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.4K
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

115
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
115

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ExtracorporeaL life support and Modification Of Hemostasis: the ELMOH trial: hemostatic changes during the first 48 h of VV- and VA-ECMO: a prospective multicenter cohort study.

Critical care (London, England)·2026
Same author

Can prothrombin time assays withstand the influence of antiprothrombin and anti-β2-glycoprotein I antibodies on the international normalized ratio?

Research and practice in thrombosis and haemostasis·2026
Same author

"Effect of direct oral anticoagulants in cirrhosis: an in vitro study": comment.

Journal of thrombosis and haemostasis : JTH·2026
Same author

ROTEM-detected hypocoagulability is associated with major non-portal hypertensive bleeding in cirrhosis.

Hepatology communications·2026
Same author

Erratum to '2023 American College of Rheumatology/European League Against Rheumatism antiphospholipid syndrome classification criteria solid phase-based antiphospholipid antibody domain-collaborative efforts of Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking and ISTH SSC to harmonize enzyme-linked immunosorbent assay and non-enzyme-linked immunosorbent assay antiphospholipid antibody tests: communication from the ISTH SSC Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibodies': [Journal of Thrombosis and Haemostasis. Volume 23, Issue 1, January 2025, Pages 341-344].

Journal of thrombosis and haemostasis : JTH·2026
Same author

The influence of antiphospholipid antibodies on prothrombin time and international normalized ratio: a scoping review.

Critical reviews in clinical laboratory sciences·2025
Same journal

Type I Interferonopathies: Fifteen Years On, From Concept to Therapeutic Perspectives.

Current rheumatology reports·2026
Same journal

Intensive Care Management of ANCA-associated Vasculitides: a Narrative Review.

Current rheumatology reports·2026
Same journal

The Role of Musculoskeletal Ultrasound in Psoriatic Arthritis: From Preclinical Detection to Treatment Monitoring.

Current rheumatology reports·2026
Same journal

Correction to: Is Gout and Autoinflammatory Disease?

Current rheumatology reports·2026
Same journal

Risks and Management of Glucocorticoid Therapy for Patients with Rheumatic Disease Having Surgery.

Current rheumatology reports·2026
Same journal

Perioperative Management Considerations for Patients with Systemic Lupus Erythematosus.

Current rheumatology reports·2026
See all related articles

Related Experiment Video

Updated: Dec 17, 2025

Antibody Profiling by Luciferase Immunoprecipitation Systems LIPS
12:19

Antibody Profiling by Luciferase Immunoprecipitation Systems LIPS

Published on: October 7, 2009

27.5K

How to Interpret Antiphospholipid Laboratory Tests.

Katrien M J Devreese1,2

  • 1Department of Laboratory Medicine, Coagulation Laboratory, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Ghent, Belgium. Katrien.devreese@uzgent.be.

Current Rheumatology Reports
|June 21, 2020
PubMed
Summary
This summary is machine-generated.

Accurate diagnosis of antiphospholipid syndrome (APS) requires careful laboratory testing for antiphospholipid antibodies (aPL). Understanding test pitfalls and integrating results is crucial for effective patient risk stratification.

Keywords:
Anti-β2 glycoprotein I antibodiesAnticardiolipin antibodiesAntiphospholipid syndromeInterferenceInterpretationLupus anticoagulant

More Related Videos

Anti-Nuclear Antibody Screening Using HEp-2 Cells
13:01

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

136.8K
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.4K

Related Experiment Videos

Last Updated: Dec 17, 2025

Antibody Profiling by Luciferase Immunoprecipitation Systems LIPS
12:19

Antibody Profiling by Luciferase Immunoprecipitation Systems LIPS

Published on: October 7, 2009

27.5K
Anti-Nuclear Antibody Screening Using HEp-2 Cells
13:01

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

136.8K
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.4K

Area of Science:

  • Clinical immunology
  • Diagnostic laboratory medicine

Background:

  • Antiphospholipid syndrome (APS) diagnosis relies on specific laboratory tests for antiphospholipid antibodies (aPL).
  • Standardization of aPL tests has advanced, but challenges in interpretation and inter-assay variability persist.

Purpose of the Study:

  • To review essential laboratory tests for diagnosing antiphospholipid syndrome (APS).
  • To highlight the importance of understanding pitfalls and interferences in antiphospholipid antibody (aPL) testing for accurate diagnosis.

Main Methods:

  • Review of current guidelines for detecting lupus anticoagulant (LAC), anticardiolipin antibodies (aCL), and anti-beta2-glycoprotein I antibodies (aβ2GPI).
  • Discussion of assay complexities, potential interferences (e.g., anticoagulant therapy), and inter-assay differences in solid-phase assays.
  • Exploration of antibody profiles and emerging aPL markers for risk stratification.

Main Results:

  • Current guidelines provide useful tools for LAC, aCL, and aβ2GPI detection.
  • LAC measurement is complex and prone to interference; solid-phase assays for aCL and aβ2GPI show variability.
  • Antibody profiles aid in identifying patients at risk, though additional aPL like aDI and aPS/PT are not yet diagnostic criteria.

Conclusions:

  • Laboratory diagnosis of APS remains challenging, necessitating comprehensive testing including LAC, aCL, and aβ2GPI (IgG and IgM).
  • Integrated interpretation of all test results with an interpretative comment is vital for diagnostic efficacy.
  • Close collaboration between clinical pathologists and clinicians is mandatory for optimal APS diagnosis and management.