Related Experiment Video
Updated: Dec 17, 2025
16:03
A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms
Published on: January 11, 2015
9.9K
Recent Advances on Marine Alkaloids from Sponges
Changhao Bian1, Jiangming Wang1, Xinyi Zhou1
1College of Food Science and Technology, Shanghai Ocean University, Shanghai, 201306, P. R. China.
Chemistry & Biodiversity
|June 21, 2020
Summary
Marine sponges are rich sources of diverse alkaloids with significant pharmacological activities. This review summarizes 149 marine alkaloids, their bioactivities, and biosynthesis, aiding future drug discovery from natural products.
Area of Science:
- Marine natural products chemistry
- Pharmacology and drug discovery
- Marine natural product biosynthesis
Background:
- Marine sponges are prolific sources of structurally diverse secondary metabolites, particularly alkaloids.
- These marine alkaloids exhibit a wide range of valuable pharmacological properties, including cytotoxic, antimicrobial, and antioxidant effects.
- Recent years have seen a surge in interest from the pharmaceutical sector regarding these compounds.
Purpose of the Study:
- To comprehensively review marine alkaloids derived from sponges, focusing on structures and bioactivities reported between 2015 and 2020.
- To analyze the environmental factors influencing alkaloid production in marine sponges.
- To discuss the biosynthetic pathways of key alkaloid classes, such as pyrrole and guanidine alkaloids, in specific sponge genera.
Main Methods:
- Systematic literature search for marine alkaloids from sponges published between 2015-2020.
- Structure elucidation and bioactivity profiling of identified alkaloids.
- Analysis of environmental data associated with alkaloid-rich sponge habitats.
- Review of published biosynthetic pathways for pyrrole and guanidine alkaloids.
Main Results:
- A curated list of 149 marine alkaloids from sponges, detailing their chemical structures and reported bioactivities.
- Identification of correlations between marine sponge habitats and alkaloid production.
- Detailed discussion on the biosynthesis of pyrrole and guanidine alkaloids from genera Agelas and Monanchora.
Conclusions:
- Marine sponges represent a significant and underexplored reservoir of pharmacologically active alkaloids.
- Understanding the environmental influences and biosynthetic routes can guide the sustainable sourcing and development of marine natural product-based drugs.
- This review provides a valuable resource for researchers in natural product chemistry and drug discovery.
More Related Videos
09:49Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation
Published on: October 31, 2019
23.0K
12:12Identification of Hemolytic and Phospholipase Activity in Crude Extracts from Sea Anemones by Straightforward Bioassays
Published on: March 29, 2022
3.2K
Related Concept Videos
01:23Red Algae
597
Red algae, also known as rhodophytes, are primarily found in marine environments, though some species inhabit freshwater and terrestrial ecosystems. These organisms exist in both unicellular and multicellular forms, with some multicellular varieties reaching macroscopic sizes.As phototrophic organisms, red algae contain chlorophyll a; however, their chloroplasts lack chlorophyll b. Instead, they possess phycobiliproteins, which serve as major light-harvesting pigments, similar to those found in...
597
01:21Green Algae
563
Green algae, also referred to as chlorophytes, are different from red algae in having the chloroplasts containing chlorophylls a and b, which give them their distinct green hue. However, they lack phycobiliproteins, preventing them from developing the red or blue-green pigmentation seen in red algae. In terms of photosynthetic pigment composition, green algae closely resemble plants and share a close evolutionary relationship with them. Taxonomically Green algae belong to Phylum Chlorophyta in...
563
01:19Other Algae
286
The group Stramenopiles include some phototrophic microorganisms. Members of this group possess flagella covered in numerous short, hairlike extensions, a feature that inspired the group's name, derived from the Latin words for "straw" and "hair." Some of the main categories of Stramenopiles include diatoms, golden algae, and brown algae.Diatoms are unicellular, photosynthetic eukaryotes, with over 200 known genera. They play a key role in the planktonic communities of both marine and...
286
01:28Overview of Algae
606
The kingdom Archaeplastida encompasses red and green algae, along with land plants. Unlike other protists with chloroplasts that arose through secondary endosymbiosis, only red and green algae originated from primary endosymbiotic events. This diverse group of eukaryotic organisms contains chlorophyll and performs oxygenic photosynthesis.Algae exist in various forms, from large brown kelp in coastal waters to green scum in puddles and stains on rocks or soil. Some species are responsible for...
606
01:27Diversity of Protists III
630
Rhizaria are a diverse group of unicellular protists characterized by their threadlike cytoplasmic extensions known as pseudopodia. These structures aid in both locomotion and feeding, giving Rhizaria an amoeboid appearance. Their amoeboid morphology once led to taxonomic confusion, but molecular phylogenetics has clarified their evolutionary placement and emphasized their shared use of pseudopodia despite divergent lineages.This clade comprises diverse lineages such as Chlorarachniophyta,...
630