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Formulation aspects of intravenous nanosuspensions
Dipeekakumari Patel1, Sandeep S Zode1, Arvind K Bansal1
1National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, Punjab 160062, India.
International Journal of Pharmaceutics
|June 21, 2020
Summary
Intravenous nanosuspensions offer a promising solution for formulating poorly water-soluble drugs, overcoming limitations of traditional methods. This review explores their development, characterization, and challenges for clinical application.
Area of Science:
- Pharmaceutical Sciences
- Nanotechnology
- Drug Delivery
Background:
- Intravenous (IV) drug delivery is crucial for rapid action and targeted delivery.
- Poorly water-soluble drugs present significant formulation challenges for IV administration.
- Existing solubilization techniques have limitations in efficacy, safety, and applicability.
Purpose of the Study:
- To provide a comprehensive overview of intravenous nanosuspension formulation development.
- To discuss the desired properties, characterization, and manufacturing of IV nanosuspensions.
- To address translational challenges, regulatory aspects, and preclinical applications of IV nanosuspensions.
Main Methods:
- Review of existing literature on IV nanosuspension technology.
- Analysis of formulation strategies, stabilization techniques, and characterization tools.
- Examination of case studies for preclinical evaluation and targeted delivery applications.
Main Results:
- IV nanosuspensions represent a viable strategy for poorly water-soluble drugs, overcoming traditional formulation barriers.
- Advancements in characterization and manufacturing are crucial for successful translational development.
- Nanosuspensions show potential in toxicological studies, clinical trials, and targeted drug delivery.
Conclusions:
- IV nanosuspensions offer a versatile platform for developing challenging IV formulations.
- Addressing translational and regulatory hurdles is key to commercializing IV nanosuspension products.
- Further research and case studies will expand the application of IV nanosuspensions from preclinical to commercial stages.
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