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Malaria According to GARP: A New Trail towards Anti-disease Vaccination
Calvin Hon1, Kai Matuschewski1
1Department of Molecular Parasitology, Institute of Biology, Humboldt University, 10115 Berlin, Germany.
Trends in Parasitology
|June 22, 2020
Abstract:
Naturally acquired anti-Plasmodium falciparum immunity protects first and foremost against severe disease. Raj et al. have established a tantalizing path towards an anti-disease vaccine by identifying glutamic acid-rich protein (GARP) antibodies as signatures of protection against severe malaria in Tanzanian children and demonstrating efficacy in blood cultures and monkey trials.