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[The interrelationships of hepatitis B e antigen antibody and HBsAg-circulating immune complexes in asymptomatic
1Department of Internal Medicine, Tri-Service General Hospital, National Defense Medicine Center, Taipei, Taiwan, R.O.C.
The prevalence of asymptomatic HBsAg carriers and positive rate of HBsAg immune complexes (HBsAg-CICs) were comparatively higher among Chinese. The former is considered to be related with hepatitis B e antigen and the latter is not clear yet. In order to investigate the relationship between HBsAg-CICs and e antigen antibody among asymptomatic carriers. 90 subjects of carriers was tested for HBsAg-CICs by PEG-trypsinisation method and for e antigen antibody by radio-immunoassay. HBsAg-CICs were positive in 66 subjects among 90 carriers. The concentration of HBsAg-CICs (ng/ml) was significantly higher among 32 subjects with positive HBeAg (333.87 +/- 265.39) than 27 subjects with positive anti-HBe (181.03 +/- 162.05), p less than 0.02. Furthermore, the positive rate of e antigen and e antibody was just contrary among carriers with positive and negative HBsAg-CICs. Among 24 subjects with negative HBsAg-CICs, the percentage of positive HBeAg was much lower than positive e antibody. A significant interrelationship was present between positive or negative HBsAg-CICs and e antigen, antibody, the statistically significant was proved by the Chi square test. The above results showed that the high prevalence of asymptomatic HBsAg carriers among Chinese may be related to e antigen.
The prevalence of asymptomatic HBsAg carriers and positive rate of HBsAg immune complexes (HBsAg-CICs) were comparatively higher among Chinese. The former is considered to be related with hepatitis B e antigen and the latter is not clear yet. In order to investigate the relationship between HBsAg-CICs and e antigen antibody among asymptomatic carriers. 90 subjects of carriers was tested for HBsAg-CICs by PEG-trypsinisation method and for e antigen antibody by radio-immunoassay. HBsAg-CICs were positive in 66 subjects among 90 carriers. The concentration of HBsAg-CICs (ng/ml) was significantly higher among 32 subjects with positive HBeAg (333.87 +/- 265.39) than 27 subjects with positive anti-HBe (181.03 +/- 162.05), p less than 0.02. Furthermore, the positive rate of e antigen and e antibody was just contrary among carriers with positive and negative HBsAg-CICs. Among 24 subjects with negative HBsAg-CICs, the percentage of positive HBeAg was much lower than positive e antibody. A significant interrelationship was present between positive or negative HBsAg-CICs and e antigen, antibody, the statistically significant was proved by the Chi square test. The above results showed that the high prevalence of asymptomatic HBsAg carriers among Chinese may be related to e antigen.