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Updated: Dec 17, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
Socioeconomic status dependent medical complexities in children with sickle cell disease in Saudi Arabia
Shahida Aziz Khan1,2, Fayza AlSiny3, Ahmad Makki1
1Applied Nutrition Group, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
Insights
Children with sickle cell disease (SCD) from lower socioeconomic status (SES) families experience more frequent vaso-occlusive crises (VOC) and adverse events. This highlights the impact of socioeconomic disparities on SCD complications.
Area of Science:
- Pediatrics
- Hematology
- Public Health
Background:
- Socioeconomic status (SES) significantly impacts health outcomes.
- Sickle cell disease (SCD) presents various complications that may be influenced by socioeconomic factors.
Purpose of the Study:
- To investigate the association between SES and clinical/hematological parameters in children with SCD in Saudi Arabia.
- To determine if lower SES correlates with increased disease severity or complications.
Main Methods:
- A cohort of 65 children (5-16 years) with SCD was classified into four socioeconomic classes based on family income (SAR).
- Assessment included frequency of vaso-occlusive crisis (VOC), adverse events, and hematological parameters.
Main Results:
- A higher proportion of children from the lowest SES class (Class 1: <5000 SAR) experienced more frequent VOC and adverse events.
- The 5-10 year age group showed increased susceptibility to adverse events and VOC.
Conclusions:
- Lower socioeconomic status is associated with a higher frequency of vaso-occlusive crises and adverse events in children with SCD.
- Findings suggest socioeconomic disparities modify clinical outcomes in pediatric SCD.
- Further large-scale studies are recommended to confirm these associations.
Abstract:
A look into the associations of socioeconomic status (SES) with prevalence of various complications in sickle cell disease (SCD) is necessary, for an improvement of societal norms, governmental health policies and strategies. We therefore studied the influence of SES indices on certain hematological and clinical parameters in children with SCD in Saudi Arabia. We included 32 female and 33 male patients aged 5-16 years, who were classified based upon their family income. Family monthly income was divided into 4 categories from lowest to highest, with socioeconomic class1 having low earnings of <5000 SAR; the middle income class divided further into class 2 with earnings >5000-10,000 SAR, and class 3 with earnings >10,000-15,000 SAR; and the higher income class 4 with earnings of >15,000 SAR. The assessment indices used were, the frequency of vaso-occlusive crisis (VOC), adverse events, and hematological parameters. A higher percentage of children affected with the disease were from class1, which is the low socio-economic class. It was found that the percentage of frequency of VOC pain crisis, and adverse events was higher in social class 1 patients than in the classes 2, 3, and 4. Also, the age group 5-10 years appeared more susceptible to adverse events and VOC. Our findings suggest the need to conduct future larger studies, to deduce the modifying influence of disparity in SES on certain clinical and hematological indices in children with SCD.
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