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Comparison of Estrogen and Progesterone Receptor Status in Tumor Mass and Axillary Lymph Node Metastasis in Patients
Shikha Singh1, Samarth Shukla1, Ashok Singh2
1Department of Pathology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Deemed to be University, Wardha, Maharashtra, India.
Introduction:
Breast malignancy is a hormone-dependent tumor. The hormone receptor status in the primary tumor is required while taking decision for starting adjuvant therapy. The estrogen receptor (ER) and progesterone receptor (PR) status is also an important prognostic marker.
Materials And Methods:
All modified radical mastectomy cases with axillary lymph node dissection were taken. H and E staining was done. All lymph node-positive breast cancer cases were subjected to immunohistochemistry using ER and PR antibodies.
Results:
In the study of 60 cases, the level of concordance between the primary tumor and the metastatic lymph node was 98.33% for ER and 96.66% for PR.
Conclusion:
There exists a positive correlation between the hormone receptor status of the primary tumor and the paired axillary lymph nodes.
