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Second primary malignancies among cancer patients
Xuanqi Zheng1, Xiao Li2, Minqi Wang3
1Department of Orthopaedics, Zhejiang Provincial Key Laboratory of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Annals of Translational Medicine
|June 23, 2020
Summary
The incidence of second primary malignancies (SPM) is rising due to better cancer survival. Liver cancer history significantly worsens SPM prognosis, highlighting the need for targeted prevention and treatment strategies.
Area of Science:
- Oncology
- Cancer Epidemiology
- Clinical Research
Background:
- Second primary malignancies (SPM) are increasingly prevalent due to advances in cancer therapy and diagnostics.
- Improved cancer survival rates contribute to a higher incidence of SPM.
- Understanding the demographics and prognostic factors of SPM is crucial.
Purpose of the Study:
- To describe the demographic characteristics of SPM patients.
- To analyze the distribution of primary cancer sites and subsequent SPM.
- To investigate factors influencing SPM prognosis.
Main Methods:
- Retrospective analysis of patients diagnosed with SPM from 2000-2013 using Surveillance, Epidemiology, and End Results (SEER) data.
- Inclusion of patients over 18 with 16 common initial cancer sites.
- Application of Cox proportional hazards regression and calculation of multiple primary standardized incidence ratio (MP-SIR).
Main Results:
- A cohort of 76,168 SPM patients was analyzed from 303,753 identified cases.
- Prostate cancer patients showed high vulnerability to SPM (34.59%); lung and bronchus were common sites for SPM (24.90%).
- Esophageal cancer survivors had the highest risk of developing secondary stomach tumors (SIR=5.08); liver cancer history was linked to poorer survival (HR=1.64).
Conclusions:
- Despite improved cancer survival, SPM incidence is rising with a concerning prognosis.
- Prognosis for SPM patients is not optimistic, necessitating further research.
- Increased focus on SPM prevention and management strategies is essential.
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