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Updated: Dec 17, 2025

Author Spotlight: Controlled Human Exposure Model for Tick Research and Lyme Disease Studies
Published on: December 1, 2023
Heartland Virus in Humans and Ticks, Illinois, USA, 2018-2019
Insights
Heartland virus, a tick-borne illness, was detected in Amblyomma americanum ticks in Illinois. This finding suggests the virus may be more widespread in the state than previously known.
Area of Science:
- * Arbovirology and Vector-Borne Diseases
- * Medical Entomology
- * Public Health Surveillance
Background:
- * Heartland virus (HRTV) is an emerging tick-borne virus responsible for human infections.
- * Previous human cases of HRTV have been reported, necessitating further investigation into its distribution.
- * Amblyomma americanum ticks are known vectors for various pathogens.
Purpose of the Study:
- * To determine the presence and distribution of Heartland virus and Bourbon virus in tick populations in Illinois.
- * To assess the potential risk of HRTV transmission to humans in the region.
Main Methods:
- * Collection of ticks from potential tick bite exposure sites across Illinois in 2019.
- * Testing of tick pools for the presence of Heartland virus and Bourbon virus using molecular methods.
Main Results:
- * Heartland virus was detected in a pool of adult male Amblyomma americanum ticks.
- * HRTV-positive tick samples were identified at two distinct locations separated by 439 km.
- * Bourbon virus was not detected in the tested tick samples.
Conclusions:
- * The detection of Heartland virus in Amblyomma americanum ticks across a wide geographic area in Illinois indicates a potentially widespread distribution.
- * These findings highlight the need for continued surveillance of tick-borne diseases and public awareness regarding tick bite prevention.
Abstract:
In 2018, Heartland disease virus infected 2 persons in Illinois, USA. In 2019, ticks were collected at potential tick bite exposure locations and tested for Heartland and Bourbon viruses. A Heartland virus-positive pool of adult male Amblyomma americanum ticks was found at 2 locations, 439 km apart, suggesting widespread distribution in Illinois.

