Electrochemical (bio) sensors go green
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Updated: Dec 17, 2025

Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules
Published on: June 1, 2011
Pramod K Kalambate1, Zhixiang Rao1, Dhanjai2
1State Key Laboratory of Materials Processing and Die & Mould Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, PR China.
Abstract:
Electrochemical (bio) sensors are now widely acknowledged as a sensitive detection tool for disease diagnosis as well as the detection of numerous species of pharmaceutical, clinical, industrial, food, and environmental origin. The term 'green' demonstrates the development of electrochemical (bio) sensing platforms utilizing biodegradable and sustainable materials. Development of green sensing platforms is one of the most active areas of research minimizing the use of toxic/hazardous reagents and solvent systems, thereby further reducing the production of chemical wastes in sensor fabrication. The present review includes green electrochemical (bio) sensors which are based on firstly, green sensors comprising natural and non-hazardous materials (e.g., paper/clay/zeolites/biowastes), secondly sensors based on nanomaterials synthesized by green methods and lastly sensors constituting green solvents (e.g., ionic liquids/deep eutectic solvents). Electrochemical performances of such green sensors and their benefits such as biodegradability, non-toxicity, sustainability, low-cost, sensitive surfaces, etc. Have been discussed for quantification of various target analytes. Associated challenges, possible solutions, and opportunities towards fabricating green electrochemical sensors and biosensors have been provided in the conclusion section.

