Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Issues And Trends In Healthcare Delivery System

Issues And Trends In Healthcare Delivery System

The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...

Alzheimer's Disease: Treatment

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Microorganisms in Medicine and Therapeutics

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

DNA Break-Induced Epigenetic Alterations Promote Plaque Formation and Behavioral Deficits in an Alzheimer's Disease Mouse Model.

bioRxiv : the preprint server for biology·2025

Same author

Emerging strategies, applications and challenges of targeting NAD<sup>+</sup> in the clinic.

Nature aging·2025

Same author

Single-Short Partial Reprogramming of the Endothelial Cells Decreases Blood Pressure via Attenuation of EndMT in Hypertensive Mice.

Circulation research·2025

Same author

Invigorating discovery and clinical translation of aging biomarkers.

Nature aging·2025

Same author

A bile acid could explain how calorie restriction slows ageing.

Nature·2024

Same author

Fertility protection during chemotherapy treatment by boosting the NAD(P)<sup>+</sup> metabolome.

EMBO molecular medicine·2024

Search research articles

Related Experiment Video

Updated: Dec 17, 2025

Author Spotlight: AI-Driven Trypanosome Species Detection from Microscopic Images

Author Spotlight: AI-Driven Trypanosome Species Detection from Microscopic Images

Published on: October 27, 2023

Can artificial intelligence identify effective COVID-19 therapies?

Michael B Schultz¹, Daniel Vera¹, David A Sinclair¹

¹Paul F. Glenn Center for Biology of Aging Research, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.

EMBO Molecular Medicine

|June 23, 2020

Summary

A rheumatoid arthritis drug shows promise against COVID-19. Research confirms its antiviral and anti-inflammatory effects, with early patient data suggesting disease improvement and supporting further clinical trials.

More Related Videos

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

Related Experiment Videos

Last Updated: Dec 17, 2025

Author Spotlight: AI-Driven Trypanosome Species Detection from Microscopic Images

Author Spotlight: AI-Driven Trypanosome Species Detection from Microscopic Images

Published on: October 27, 2023

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

Area of Science:

Virology
Immunology
Drug Repurposing

Background:

The COVID-19 pandemic necessitates novel therapeutic strategies.
Rheumatoid arthritis treatments are being investigated for repurposing against SARS-CoV-2.
Artificial intelligence aids in predicting drug efficacy for new diseases.

Purpose of the Study:

To validate an AI-driven prediction for repurposing a rheumatoid arthritis drug against COVID-19.
To investigate the drug's antiviral and anti-inflammatory mechanisms in SARS-CoV-2 infection.
To assess the preliminary clinical correlation between drug administration and COVID-19 patient outcomes.

Main Methods:

Utilized liver organoids infected with SARS-CoV-2 to model viral infection.
Confirmed dual antiviral and anti-inflammatory activities of the rheumatoid arthritis drug.
Observed clinical outcomes in four COVID-19 patients receiving the drug.

Main Results:

The rheumatoid arthritis drug demonstrated significant antiviral activity against SARS-CoV-2 in vitro.
The drug exhibited potent anti-inflammatory effects relevant to COVID-19 pathogenesis.
Administration in four COVID-19 patients was correlated with clinical improvement.

Conclusions:

The study validates the AI-predicted potential of a rheumatoid arthritis drug for COVID-19 treatment.
Dual antiviral and anti-inflammatory actions support its therapeutic candidacy.
Preliminary patient data warrants larger placebo-controlled trials for definitive efficacy assessment.