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Conformable polyimide-based μECoGs: Bringing the electrodes closer to the signal source.

Maria Vomero¹, Maria Francisca Porto Cruz², Elena Zucchini³

¹Department of Microsystems Engineering (IMTEK), University of Freiburg, Germany; BrainLinks-BrainTools Center, University of Freiburg, Germany; Currently at Department of Electrical Engineering (SEAS), Columbia University, New York City, USA.

|June 23, 2020

Summary

Optimizing bioelectronic devices requires understanding conformability. This study reveals that device geometry and tissue curvature, not just material stiffness, are crucial for stable, long-term neural implants.

Keywords:

Bioelectronics Brain recording Chronic stability Conformability Polyimide-based electrocorticography device Tissue-electrode interface

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Area of Science:

Biomedical Engineering
Neuroscience
Materials Science

Background:

Chronic stability of bioelectronic devices is critical for long-term use.
Minimizing foreign body response in neurotechnologies is key.
Current devices often balance mechanical matching with robustness.

Purpose of the Study:

To determine the conformability threshold for polyimide-based electrocorticography (ECoG) devices.
To investigate the relationship between device mechanics, tissue interaction, and implant stability.
To establish design principles for reliable neural implants.

Main Methods:

Utilized a finite element model to simulate cortical depression from ECoG devices.
Validated mechanical models in vivo using rat models.
Performed long-term impedance measurements (40 days) and multi-unit activity recordings (12 weeks).

Main Results:

Conformability threshold was analytically determined for polyimide ECoG devices.
Mechanical simulations predicted cortical depression based on device properties.
In vivo impedance and neural recordings confirmed superior stability of conformable implants.

Conclusions:

Device conformability is essential for steady and reliable neural implants.
Conformability depends on material properties, tissue curvature, device thickness, and geometry.
Optimized conformability enhances the biotic/abiotic interface and long-term device performance.