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JAK3 is a potential biomarker and associated with immune infiltration in kidney renal clear cell carcinoma

Feiguo Liang1, Hao Liang2, Zuwei Li2

  • 1Department of Hand and Foot Microsurgery, Maoming People's Hospital, Maoming 525000, China.

International Immunopharmacology
|June 23, 2020
PubMed

Insights

Janus kinase 3 (JAK3) is elevated in kidney renal clear cell carcinoma (KIRC), correlating with poorer survival and immune cell infiltration. JAK3 may serve as a potential biomarker for KIRC prognosis and immune response.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Kidney renal clear cell carcinoma (KIRC) is a prevalent cancer with a poor prognosis.
  • The Janus kinase (JAK) family is crucial for cell proliferation, metastasis, invasion, and immune responses.

Purpose of the Study:

  • To investigate the expression and clinical significance of Janus kinase 3 (JAK3) in KIRC.
  • To explore the association of JAK3 with immune cell infiltration and related signaling pathways in KIRC.

Main Methods:

  • Utilized web-portals to analyze JAK3 expression in KIRC tissues.
  • Correlated JAK3 levels with patient survival rates (disease-free and overall survival).
  • Performed enrichment analysis to identify JAK3-associated functions and pathways, including immune response and JAK-STAT signaling.

Main Results:

  • JAK3 expression was significantly upregulated in KIRC tissues.
  • High JAK3 levels correlated with decreased disease-free and overall survival rates in KIRC patients.
  • JAK3 expression showed significant correlations with immune cell abundance and immune biomarkers.
  • Enrichment analysis linked JAK3 to immune response, JAK-STAT, and Ras signaling pathways.
  • Identified potential kinase, miRNA, and transcription factor targets of JAK3 in KIRC.

Conclusions:

  • JAK3 is a potential prognostic biomarker in KIRC.
  • JAK3 expression is associated with immune infiltration and key cancer-related signaling pathways in KIRC.
Keywords:
BiomarkerImmunotherapyJAK3KIRC

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