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Updated: Dec 17, 2025

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

How Have Experimental Cancer Interventions Evolved over Time?

Ziran Li¹, Huanyao Chen¹, Chi Yuan¹

¹Department of Biomedical Informatics, Columbia University, New York, NY, USA.

Studies in Health Technology and Informatics

|June 24, 2020

Summary

This study analyzed cancer clinical trials from 2000-2017, finding drug interventions dominate, with immunologic drugs rapidly increasing. Breast cancer research shows steady progress, while pancreatic cancer research trends are reversing.

Keywords:

Clinical Trials Data Science Trend Analysis

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Area of Science:

Oncology
Clinical Trials Research
Biostatistics

Background:

Cancer experimental interventions encompass a wide range of therapies, including drugs, radiation, and surgery.
Understanding trends in clinical trials is crucial for evaluating the evolving landscape of cancer research and treatment development.

Purpose of the Study:

To analyze trends in experimental cancer interventions from 2000 to 2017 using data from the AACT database.
To compare research progress and drug intervention patterns between breast cancer and pancreatic cancer clinical trials.

Main Methods:

Downloaded and analyzed records of 32,623 interventional neoplasm clinical trials.
Normalized intervention and drug concepts using MetaMap and calculated normalized frequencies (NF).
Utilized JS Distance to assess research trends across three distinct time periods.

Main Results:

Drug interventions constituted the majority (77.4%) of all interventions, with immunologic drugs showing rapid growth.
Breast cancer trials featured more phase 3/4 drugs and comparator arms than pancreatic cancer trials, with a more even drug NF distribution.
Breast cancer research demonstrated a unidirectional trend, while pancreatic cancer research exhibited a reverse trend over time.

Conclusions:

The study provides a comprehensive overview of experimental cancer intervention trends, highlighting the increasing role of immunologic drugs.
Comparative analysis reveals distinct research trajectories for breast and pancreatic cancer, with breast cancer showing more consistent progress.
The methodology offers a framework for leveraging public clinical trial data to understand evolving cancer research landscapes.