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Published on: January 12, 2019
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[Basaloid squamous cell carcinoma in gingiva: a case report]
Lu-Ling Dai1, Xiu-Xiu Yang1, Hao-Wei Zhao1
1State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Pathology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Summary
Basaloid squamous cell carcinoma (BSCC) is a rare oral cancer. This case study details a gingival BSCC, successfully treated with surgery, highlighting its unusual presentation and management.
Area of Science:
- Oral and Maxillofacial Surgery
- Oncology
- Pathology
Background:
- Basaloid squamous cell carcinoma (BSCC) is an aggressive malignancy with rare occurrences in the oral and maxillofacial region.
- Gingival involvement by BSCC is exceptionally uncommon, presenting diagnostic and therapeutic challenges.
Observation:
- A 78-year-old male presented with left maxillary pain due to a gingival mass.
- Microscopic examination revealed comedo necrosis and peripheral palisading, with glandular-like structures.
- Immunohistochemistry showed a Ki-67 score of 28%, positive S-100 in some areas, and negative P16 and CK7.
Findings:
- The case was diagnosed as basaloid squamous cell carcinoma based on pathological and immunohistochemical findings.
- The patient underwent subtotal maxillectomy and remained disease-free at 12 months post-surgery.
- Literature review analyzed clinicopathological features, diagnosis, treatment, and prognosis of BSCC.
Implications:
- Surgery is the primary treatment for head and neck BSCC.
- Adjuvant radiation-chemotherapy may be considered for human papilloma virus-positive cases.
- This case underscores the importance of recognizing rare presentations of BSCC in the gingiva.
