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Deep Brain Stimulation with Simultaneous fMRI in Rodents
Published on: February 15, 2014
Improving Safety of MRI in Patients with Deep Brain Stimulation Devices
Alexandre Boutet1, Clement T Chow1, Keshav Narang1
1From the University Health Network, Toronto, Canada (A.B., C.T.C., K.N., G.J.B.E., C.N., J.G., A.L., W.K., A.M.L.); Joint Department of Medical Imaging, University of Toronto, Toronto, Canada (A.B., W.K.); Department of Neurosurgery, West Virginia University, Morgantown, WVa (M.R., A.R.R.); Department of Neurosurgery, Rockefeller Neuroscience Institute, Morgantown, WVa (M.R., A.R.R.); Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, Calif (A.J.M.); Department of Psychology, Concordia University, Montreal, Canada (C.J.S.); Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany (C.J.S.); Center for Scientific Review, National Institutes of Health, Bethesda, Md (I.H.); and Division of Neurosurgery, Department of Surgery, Toronto Western Hospital and University of Toronto, 399 Bathurst St, WW 4-437, Toronto, ON, Canada M5T 2S8 (A.M.L.).
Magnetic Resonance Imaging (MRI) is safe for patients with deep brain stimulation (DBS) devices when following guidelines. Research is expanding MRI
Area of Science:
- Neurology
- Medical Imaging
- Biomedical Engineering
Background:
- Deep brain stimulation (DBS) is a crucial therapy, but MRI compatibility poses challenges.
- Existing regulations limit MRI use in patients with DBS devices due to safety concerns.
Purpose of the Study:
- To evaluate the safety and utility of MRI in patients with DBS devices.
- To review current risks and guidelines for MRI in this population.
Main Methods:
- Analysis of risks including electrode tip heating, induced currents, and device malfunction.
- Review of phantom studies and clinical data on MRI safety in DBS patients.
Main Results:
- Electrode tip heating is the primary risk identified in phantom models.
- No adverse events reported in patients imaged following vendor guidelines, indicating general safety.
- Potential for MRI use outside established guidelines with sufficient safety data.
Conclusions:
- Current guidelines ensure safe MRI practices for DBS patients.
- Ongoing research focuses on enhancing DBS device and MRI safety through simulation models.
- Expanded MRI use can benefit both clinical care and research for DBS patients.
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