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Related Experiment Videos

Fibrinopeptide A during normal pregnancy.

R Romero1, F R Rickles, E Matthews

  • 1Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06510-8063.

American Journal of Perinatology
|January 1, 1988
PubMed
Summary

Plasma Fibrinopeptide A (FPA) levels increase significantly during pregnancy, reflecting heightened thrombin activity. These findings establish normal FPA values throughout gestation, indicating increased fibrin generation.

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Area of Science:

  • Biochemistry
  • Hematology
  • Reproductive Medicine

Background:

  • Fibrinopeptide A (FPA) is released from fibrinogen by thrombin action.
  • Plasma FPA levels indicate fibrinogen cleavage rate due to rapid clearance.
  • Establishing normal FPA values during pregnancy is crucial for understanding hemostasis.

Purpose of the Study:

  • To determine normal plasma Fibrinopeptide A (FPA) levels in pregnant women.
  • To assess changes in FPA levels across different gestational ages.
  • To correlate FPA levels with thrombin activity during pregnancy.

Main Methods:

  • Prospective study design.
  • Recruitment of 136 pregnant women and 30 non-pregnant controls.
  • Measurement of plasma FPA concentrations.

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Main Results:

  • Mean FPA was 2.8 ng/ml in pregnant women vs. 1.24 ng/ml in controls (P < 0.0001).
  • Median FPA increased with gestational age: 1.5 ng/ml (1st trimester), 1.8 ng/ml (2nd), and 2.5 ng/ml (3rd).
  • Third-trimester FPA levels were significantly higher than in the first and second trimesters.

Conclusions:

  • Plasma FPA levels are elevated in normal pregnancy.
  • Increased FPA suggests heightened thrombin activity and fibrin generation during gestation.
  • Study provides reference ranges for FPA in pregnancy.