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Endogenous Opiates and Behavior: 2018.

Richard J Bodnar1

  • 1Department of Psychology and Neuropsychology Doctoral Sub-Program, Queens College, City University of New York, Flushing, NY, 11367, United States.

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PubMed
Summary
This summary is machine-generated.

This review covers 2018 research on the endogenous opioid system, detailing how manipulating opioid peptides and receptors impacts behavior, pain, and various physiological functions.

Keywords:
Beta-endorphinDelta opioid receptorDynorphinEndomorphinsEnkephalinsKappa opioid receptorMu opioid receptorOrphanin/FQ

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • The endogenous opioid system plays a crucial role in regulating numerous physiological and behavioral processes.
  • Understanding the intricate mechanisms of this system is vital for addressing conditions ranging from pain to mood disorders.

Purpose of the Study:

  • To provide a comprehensive annual review of research published in 2018 concerning the endogenous opioid system.
  • To synthesize findings on the behavioral effects of molecular, pharmacological, and genetic manipulations of opioid peptides and receptors.

Main Methods:

  • Systematic review and anthological summary of scientific articles published in 2018.
  • Categorization of research based on specific physiological and behavioral domains influenced by the opioid system.

Main Results:

  • The review covers diverse topics including pain, analgesia, tolerance, dependence, stress, learning, memory, eating, drug abuse, mood, neurological disorders, and cardiovascular, respiratory, and immune functions.
  • Findings highlight the broad impact of opioid system modulation across multiple biological systems.

Conclusions:

  • The endogenous opioid system remains a critical area of research with far-reaching implications for human health.
  • Continued investigation into opioid peptides and receptors is essential for developing novel therapeutic strategies.