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Updated: Dec 17, 2025

Preparation and Implantation of Electrodes for Electrically Kindling VGAT-Cre Mice to Generate a Model for Temporal Lobe Epilepsy
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Advances in Understanding CREB Signaling-Mediated Regulation of the Pathogenesis and Progression of Epilepsy

Guangming Wang1, Zhanpeng Zhu1, Dahai Xu2

  • 1Department of Neurosurgery, The First Hospital of Jilin University, Changchun, 130021, Jilin, China.

Clinical Neurology and Neurosurgery
|June 24, 2020
PubMed

Insights

The transcription factor cyclic adenosine monophosphate response element binding protein (CREB) plays a role in epilepsy. Its phosphorylation is key to signaling pathways involved in the disease progression.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Epilepsy is a neurological disorder with complex underlying mechanisms.
  • The transcription factor cyclic adenosine monophosphate response element binding protein (CREB) has been implicated in the etiology of epilepsy.
  • CREB phosphorylation is a critical step in cellular signaling pathways relevant to neurological function.

Purpose of the Study:

  • To review recent discoveries on the association between CREB and epilepsy.
  • To explore the molecular and structural characteristics of CREB in the context of epilepsy.
  • To examine the role of the CREB signaling pathway in epilepsy pathogenesis and progression.

Main Methods:

  • Literature review of recent studies on CREB and epilepsy.
  • Analysis of molecular and structural aspects of CREB.
  • Investigation of the CREB signaling pathway's involvement in epilepsy.

Main Results:

  • CREB is involved in the etiology of epilepsy.
  • CREB phosphorylation is crucial for extracellular signal transmission.
  • Activation of downstream target genes by CREB signaling contributes to epilepsy pathogenesis.

Conclusions:

  • CREB and its signaling pathway are significant factors in epilepsy.
  • Understanding CREB's role offers potential therapeutic targets for epilepsy.
  • Further research into CREB's molecular characteristics is warranted for epilepsy.
Keywords:
CREBEpilepsyPathogenesis

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