Related Experiment Video
Updated: Dec 17, 2025
05:53
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
10.5K
Polymorphic Appetite Effects on Waist Circumference Depend on rs3749474 CLOCK Gene Variant
Isabel Espinosa-Salinas1, Rodrigo San-Cristobal1, Gonzalo Colmenarejo1
1IMDEA-Food Institute, CEI UAM+CSIC, 28049 Madrid, Spain.
Nutrients
|June 25, 2020
Summary
The CLOCK gene variant rs3749474 influences waist circumference based on appetite levels. Risk allele carriers experienced a significant increase in waist circumference related to appetite status.
Area of Science:
- Chronobiology
- Genetics
- Obesity Research
Background:
- Chronobiological factors, particularly CLOCK genes, are linked to obesity.
- Existing research shows CLOCK gene associations with energy intake and abdominal obesity.
- The interplay between CLOCK gene variants, appetite, and chrononutrition requires further investigation.
Purpose of the Study:
- To investigate interactions between CLOCK genetic variants and appetite status.
- To identify how these interactions affect adiposity-related variables.
Main Methods:
- Recruited 442 participants (329 women, 113 men) aged 18-65.
- Collected anthropometric, dietary, and lifestyle data.
- Utilized multiple linear regression and Bonferroni correction to analyze genotype x appetite status interactions on adiposity.
Main Results:
- A significant interaction was found between appetite status and the rs3749474 CLOCK polymorphism on waist circumference (p < 0.001).
- Carriers of the risk allele for rs3749474 showed an approximate 14 cm increase in waist circumference per appetite level increment.
- Appetite's effect on waist circumference appears modulated by the rs3749474 CLOCK polymorphism.
Conclusions:
- The rs3749474 CLOCK gene variant plays a role in modulating the relationship between appetite and waist circumference.
- Chrononutrition research should consider genetic predispositions like CLOCK polymorphisms in relation to appetite and obesity.
Related Concept Videos
01:11Genome-wide Association Studies-GWAS
15.1K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
15.1K
01:18Polygenic Traits
68.6K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
68.6K
01:28Human Genetics
1.3K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
1.3K
02:26Comparing Copy Number Variations and SNPs
18.5K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
18.5K
01:30Regulation of Food Intake
2.1K
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
2.1K
01:25Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
155
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
155