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The genetic and pharmacogenomic landscape of snoRNAs in human cancer

Yaoming Liu1,2, Hang Ruan1, Shengli Li1

  • 1Department of Biochemistry and Molecular Biology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.

Molecular Cancer
|June 25, 2020
PubMed

Insights

Small nucleolar RNAs (snoRNAs) play roles in cancer, but their genetic and drug response patterns were unknown. This study maps snoRNA genetics and their impact on cancer drug responses, aiding targeted therapy development.

Area of Science:

  • Genomics
  • Molecular Biology
  • Cancer Research

Background:

  • Small nucleolar RNAs (snoRNAs) are increasingly recognized for their involvement in tumorigenesis.
  • A comprehensive understanding of the genetic and pharmacogenomic landscape of snoRNAs is lacking.
Keywords:
CancerGenetic variantsPharmacogenomicsSmall nucleolar RNA

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