Mesotherapy: From Historical Notes to Scientific Evidence and Future Prospects

Area of Science:

• Dermatology
• Pharmacology
• Pain Management

Background:

• Intradermal therapy, commonly known as mesotherapy, involves targeted drug delivery into the dermis using short needles.
• This method modulates drug kinetics, leading to slower absorption and extended local action.
• Mesotherapy is recognized for its application in localized pain syndromes and other clinical conditions.

Purpose of the Study:

• To provide a position paper on the evidence-based application of intradermal therapy.
• To establish a scientific rationale for mesotherapy indications and technique.
• To shift the application of intradermal therapy from personal bias to scientific evidence.

Main Methods:

• Review of scientific evidence supporting intradermal therapy.
• Consensus building on technique execution modalities and nonpharmacological mechanisms.
• Analysis of indications where systemic drug-sparing or synergistic effects are beneficial.

Main Results:

• Intradermal therapy offers prolonged local effects and can be beneficial when systemic treatments are not ideal.
• The technique is suitable for localized pain and other conditions, especially when other therapies have failed or cannot be used.
• A consensus exists regarding the scientific rationale, technique, and informed consent for mesotherapy.

Conclusions:

• Intradermal therapy (mesotherapy) provides a valuable option for specific clinical conditions, particularly localized pain.
• The Italian Mesotherapy Society advocates for an evidence-based approach to mesotherapy application.
• Further research, including randomized clinical trials, may enhance the understanding and application of this technique.