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Heparin inhibits the inositol 1,4,5-trisphosphate-induced Ca2+ release from rat liver microsomes
P J Cullen1, J G Comerford, A P Dawson
1School of Biological Sciences, University of East Anglia, Norwich, England.
FEBS Letters
|February 8, 1988
Abstract:
Inositol 1,4,5-trisphosphate (Ins (1,4,5)P3)-stimulated Ca2+ release is inhibited by low concentrations of heparin (IC50 = 4.5 micrograms/ml). GTP-stimulated Ca2+ release is unaffected at a heparin concentration of 16 micrograms/ml. Addition of heparin after Ins (1,4,5)P3 causes the rapid re-uptake of Ins (1,4,5)P3-releasable Ca2+.