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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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mTOR Signaling and Cancer Progression03:03

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Related Experiment Video

Updated: Dec 17, 2025

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
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Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

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Leptin in Tumor Microenvironment.

Adriano Angelucci1, Letizia Clementi2, Edoardo Alesse2

  • 1Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy. adriano.angelucci@univaq.it.

Advances in Experimental Medicine and Biology
|June 25, 2020
PubMed
Summary
This summary is machine-generated.

Leptin, a hormone regulating energy balance, may promote cancer progression. Elevated leptin levels and its actions within the tumor microenvironment can stimulate tumor growth and influence cancer development.

Keywords:
AdipocytesAngiogenesisBreast cancerCancer progressionCancer-associated fibroblastsEndothelial cellsEstrogenFibrosisInflammationLeptinLeptin receptorMesenchymal stem cellsObesitySignal transductionTumor microenvironment

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Area of Science:

  • Endocrinology
  • Oncology
  • Cell Biology

Background:

  • Leptin is a key hormone in energy balance, appetite suppression, and weight regulation.
  • Emerging research suggests leptin has roles beyond energy homeostasis, including in immune and reproductive functions.
  • Elevated leptin levels, common in obesity, are linked to increased cancer risk and progression.

Purpose of the Study:

  • To review the mechanisms regulating leptin availability.
  • To explore how leptin influences the tumor microenvironment.
  • To understand leptin's role in cancer progression.

Main Methods:

  • Literature review of studies on leptin's physiological roles.
  • Analysis of research on leptin signaling in cancer.
  • Examination of leptin's impact on tumor microenvironment components.

Main Results:

  • Leptin's peripheral availability is regulated by various mechanisms.
  • Leptin acts on non-tumoral cells within the tumor microenvironment, fostering a pro-cancerous environment.
  • Leptin can exert paracrine and autocrine effects within the tumor microenvironment.

Conclusions:

  • Leptin's diverse physiological roles extend to cancer progression.
  • Leptin produced within the tumor microenvironment contributes to cancer growth.
  • Understanding leptin's modulation of the tumor microenvironment is crucial for cancer research.