Two-Dimensional Device with Light-Controlled Capability for Treatment of Cancer-Relevant Infection Diseases
Yanbing Yang1,2, Bo Zeng1, Jing Guo1
1Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China.
Analytical Chemistry
|June 25, 2020
Summary
This study introduces a novel black phosphorus device that uses near-infrared light to capture and release pathogens from blood for drug-resistance testing in cancer patients. This innovation aids in diagnosing concurrent infections and personalizing cancer treatment.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Infectious Disease Diagnostics
Background:
- Concurrent infections significantly increase cancer mortality, necessitating improved diagnostic tools.
- Current methods struggle with rapid, reliable pathogen detection and release for analysis in complex biological samples like blood.
- Accurate diagnosis of concurrent infections is crucial for effective, targeted cancer therapy.
Purpose of the Study:
- To develop a near-infrared (NIR) light-responsive device for capturing and releasing pathogens from serum for drug-resistance analysis.
- To create a functionalized nanostructure capable of efficient and selective pathogen capture.
- To demonstrate the utility of light-induced pathogen release for downstream genetic analysis.
Main Methods:
- Modification of black phosphorus (BP) nanostructures with aptamers for enhanced pathogen binding.
- Utilizing NIR light to induce a thermal effect for controlled release of captured pathogens.
- Performing downstream genetic analysis to determine pathogen drug resistance.
Main Results:
- Aptamer-modified BP nanostructures demonstrated high efficiency and selectivity in capturing pathogens from serum.
- NIR light irradiation successfully triggered the release of captured pathogens via a localized thermal effect.
- Downstream genetic analysis confirmed ampicillin resistance in the released pathogen.
Conclusions:
- The developed NIR light-responsive BP device enables efficient pathogen capture and release for drug-resistance testing.
- This technology holds significant potential for improving concurrent infection diagnosis in cancer patients.
- The device supports personalized healthcare by facilitating targeted cancer therapy and monitoring pathogen behavior.
