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Retinal vein occlusion and chronic kidney disease: A meta-analysis

Li Jian Fang1,2, Li Dong1, Yi Fan Li1

  • 1Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

European Journal of Ophthalmology
|June 25, 2020
PubMed

Insights

Chronic kidney disease (CKD) is more prevalent in patients with retinal vein occlusion (RVO), particularly central RVO. Conversely, end-stage renal disease patients show a higher incidence of RVO, supporting a significant link between these conditions.

Area of Science:

  • Ophthalmology
  • Nephrology
  • Public Health

Background:

  • Retinal vein occlusion (RVO) and chronic kidney disease (CKD) are significant health concerns.
  • Understanding the relationship between RVO and CKD is crucial for patient management and public health strategies.

Purpose of the Study:

  • To conduct a meta-analysis assessing the correlation between RVO and CKD.
  • To determine the prevalence of CKD in RVO patients and RVO in end-stage renal disease (ESRD) patients.

Main Methods:

  • A systematic literature search was conducted across major databases (PubMed, Embase, Web of Science, Cochrane Library).
  • Population-based studies investigating CKD as an associated factor for RVO, central RVO (CRVO), or branch RVO (BRVO) were included.
  • Data from 12 eligible studies, encompassing 23,656,214 individuals, were pooled for quantitative synthesis.

Main Results:

  • The pooled prevalence of CKD in the RVO group was 10.9% (95% CI: 6.6%, 15.1%).
  • The pooled prevalence of any RVO in the ESRD group was 1.8% (95% CI: 1.6%, 2.1%).
  • CKD prevalence was significantly higher in RVO patients (OR: 3.30; P < 0.001), with CRVO subjects showing higher CKD prevalence than BRVO patients (OR: 2.17; P = 0.004).
  • ESRD patients had a significantly higher prevalence of RVO (OR: 2.19; P < 0.001), CRVO (OR: 2.61; P < 0.001), and BRVO (OR: 2.01; P < 0.001) compared to non-ESRD subjects.

Conclusions:

  • A notable increase in CKD prevalence is observed in RVO patients, especially those with CRVO.
  • Conversely, ESRD patients exhibit an elevated prevalence of RVO.
  • The findings strongly support a significant correlation between RVO and CKD.
Abstract

Keywords:
Retinal vein occlusionchronic kidney diseaseend stage renal diseasemeta-analysisrisk factor

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