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Updated: Dec 17, 2025

A Hydrogen-Deuterium Exchange Mass Spectrometry HDX-MS Platform for Investigating Peptide Biosynthetic Enzymes
Published on: May 4, 2020
HaDeX: an R package and web-server for analysis of data from hydrogen-deuterium exchange mass spectrometry
Weronika Puchała1, Michał Burdukiewicz2, Michał Kistowski1
1Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw 02-106, Poland.
Motivation:
Hydrogen-deuterium mass spectrometry (HDX-MS) is a rapidly developing technique for monitoring dynamics and interactions of proteins. The development of new devices has to be followed with new software suites addressing emerging standards in data analysis.
Results:
We propose HaDeX, a novel tool for processing, analysis and visualization of HDX-MS experiments. HaDeX supports a reproducible analytical process, including data exploration, quality control and generation of publication-quality figures.
Availability And Implementation:
HaDeX is available primarily as a web-server (http://mslab-ibb.pl/shiny/HaDeX/), but its all functionalities are also accessible as the R package (https://CRAN.R-project.org/package=HaDeX) and standalone software (https://sourceforge.net/projects/HaDeX/).
Supplementary Information:
Supplementary data are available at Bioinformatics online.
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