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Coagulation Panel in Patients with SARS-CoV2 Infection (COVID-19)

Kerbi Alejandro Guevara-Noriega1,2, Gustavo Adolfo Lucar-Lopez3, Giselle Nuñez4

  • 1Vascular Surgery Department, Parc Tauli University Hospital, Sabadell, Spain kerbiguevara@hotmail.com.

Annals of Clinical and Laboratory Science
|June 26, 2020
PubMed

Insights

COVID-19 patients show significantly altered coagulation. Fibrinogen and D-Dimer levels are key indicators of severity and can guide anticoagulant therapy for better prognosis in SARS-CoV-2 infection.

Area of Science:

  • Medical Research
  • Infectious Diseases
  • Hematology

Background:

  • The 2019 novel coronavirus (SARS-CoV-2) causes COVID-19, declared a global epidemic in January 2020.
  • Abnormal coagulation parameters are recognized as prognostic indicators for COVID-19 severity.
  • Understanding these coagulation changes is crucial for patient management.

Purpose of the Study:

  • To summarize current literature on coagulation abnormalities in COVID-19 patients.
  • To identify key coagulation parameters affected by SARS-CoV-2 infection.
  • To explore the prognostic value of these alterations and their role in guiding therapy.

Main Methods:

  • An electronic literature search was conducted using the WHO database for COVID-19 publications.
  • Key coagulation parameters investigated include Thrombin Time (TT), Prothrombin Time (PT), Fibrinogen (FIB), Activated Partial Thromboplastin Time (APPT), and D-Dimer.
  • Data on coagulation function panels in critical COVID-19 patients were analyzed.

Main Results:

  • Coagulation function is significantly deranged in SARS-CoV-2 infected patients compared to healthy individuals.
  • Fibrinogen (FIB) and D-Dimer/Fibrin Degradation Products (DD/FDP) are the most significantly altered values.
  • Elevated D-Dimer/FDP levels correlate with disease severity.

Conclusions:

  • Early detection of coagulation alterations, particularly FIB and D-Dimer/FDP, is vital for therapeutic decisions.
  • Markedly elevated D-Dimer can guide the initiation of anticoagulation therapy and assess prognosis.
  • Routine monitoring of PT, FIB, D-Dimer/FDP, and platelets is recommended for all admitted COVID-19 patients, with daily testing suggested.

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