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Extending platelet storage to seven days using the Platelet PGD Test significantly reduces waste and saves costs. This FDA-approved safety measure enhances platelet availability for transfusions.

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Area of Science:

  • Transfusion Medicine
  • Blood Banking
  • Microbiology

Background:

  • Room temperature storage of platelets for transfusion in the US poses a risk of bacterial transmission and sepsis.
  • Current five-day storage limits lead to a national outdate rate of approximately 16%.

Purpose of the Study:

  • To evaluate the impact of extending platelet storage to seven days using the Platelet PGD Test on reducing outdating and associated costs.
  • To assess the effectiveness of FDA-cleared safety measures in enhancing platelet availability.

Main Methods:

  • A survey was conducted in 2018-2019 of 16 blood collection centers and 66 hospitals utilizing the Platelet PGD Test for seven-day storage.
  • Institutions surveyed accounted for 21-22% of the annual US platelet transfusion volume.

Main Results:

  • Blood centers reported a mean outdate reduction of 69% and mean cost savings of $415,000.
  • Hospitals reported a mean outdate reduction of 74% and mean cost savings of $176,803.
  • Over 42,000 platelet doses were saved annually across surveyed institutions, representing over 2% of US transfusions.

Conclusions:

  • Extending platelet shelf-life to seven days with the PGD Test significantly reduces product outdating and increases availability.
  • This strategy is cost-effective, with savings exceeding bacterial testing expenses.
  • The findings align with FDA Final Guidance recommendations for mitigating bacterial risks in platelet transfusions.