Related Experiment Video
Updated: Dec 17, 2025
Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
Published on: June 26, 2013
Alterations of Interhemispheric Functional Connectivity in Parkinson's Disease With Depression: A Resting-State
Haiyan Liao1, Jie Fan2, Qin Shen1
1Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Background:
Depression is the most common non-motor symptom in patients with Parkinson's disease (PD) with unknown mechanisms, but the diagnostic criteria of PD with depression (PDD) are not uniform.
Purpose:
The aim of the study was to investigate interhemispheric interactions between PDD patients and patients with PD without depression (PDND).
Methods:
The voxel-mirrored homotopic connectivity (VMHC) combined with the seed-based method was used to investigate intrinsic resting-state functional connectivity (RSFC) in 33 PDD patients, 60 PDND, and 47 healthy controls (HCs).
Results:
PDD patients exhibited a decreased VMHC in the bilateral medial frontal gyrus and paracentral lobule (MFG/PCL) than did PDND patients. Parkinson's disease with depression had a decreased VMHC in the bilateral precentral gyrus than had PDND and HC (p < 0.05). Parkinson's disease with depression had a decreased homotopic RSFC from the medial frontal gyrus (MFG)/PCL to the contralateral supplementary motor area (SMA) than had PDND (p < 0.05). The decreased homotopic RSFC from the right MFG/PCL to the left SMA was negatively correlated with Hamilton Depression Rating Scale scores (p < 0.05), but not with illness duration, Beck's Depression Inventory, and Unified Parkinson's Disease Rating Scale in PD patients.
Conclusions:
Our findings indicated that the occurrence of depression in Parkinson's disease is associated with the dysfunctional connectivity from the MFG/PCL to the contralateral SMA, which could be used as potential neuroimaging markers for the diagnosis of depression in PD patients.
More Related Videos
10:43Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
Published on: July 1, 2014
07:56Resting-State Connectivity and Neuroimaging of Prefrontal Cortex Activity During a Block-Design Yoga Asana Practice Using fNIRS
Published on: June 24, 2025