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Updated: Dec 17, 2025

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Multiparity, Brain Atrophy, and Cognitive Decline.

Joon Hyung Jung1, Ga Won Lee2, Jun Ho Lee3

  • 1Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea.

Frontiers in Aging Neuroscience
|June 26, 2020
PubMed
Summary

Grand multiparity, having five or more childbirths, is linked to brain atrophy and lower cognitive scores in older women. This suggests a potential risk factor for cognitive decline independent of amyloid plaques.

Keywords:
Alzheimer’s diseasebeta-amyloidchildbirthhippocampusmultiparityneurodegeneration

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Area of Science:

  • Neuroscience
  • Gerontology
  • Reproductive Health

Background:

  • Grand multiparity (≥5 childbirths) is associated with increased Alzheimer's disease (AD) dementia risk.
  • Pathological links between grand multiparity and cognitive decline remain unclear.
  • This study investigates multiparity's association with brain changes and cognitive function.

Purpose of the Study:

  • To examine the relationship between multiparity and cerebral amyloid-beta (Aβ) deposition.
  • To investigate the association of multiparity with brain atrophy (hippocampal and cortical).
  • To assess the link between multiparity and white matter hyperintensities (WMHs).

Main Methods:

  • Included 237 older women (148 cognitively normal, 89 mild cognitive impairment) from the KBASE cohort.
  • Utilized 11C-Pittsburgh Compound B PET, MRI, and neuropsychological assessments.
  • Analyzed associations between parity, Aβ deposition, brain volumes, WMH volume, and MMSE scores.

Main Results:

  • Grand multiparity was associated with significantly reduced hippocampal and cortical volumes.
  • Lower mini-mental status examination (MMSE) scores were observed in women with grand multiparity.
  • No association found between grand multiparity and Aβ deposition or WMH volume.

Conclusions:

  • Grand multiparity may contribute to cognitive decline by promoting amyloid-independent hippocampal or cortical atrophy.
  • Findings suggest a potential mechanism for increased dementia risk in women with high parity.
  • Highlights the importance of considering reproductive history in understanding female cognitive aging.