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Related Concept Videos

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Related Experiment Video

Updated: Dec 17, 2025

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model
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Cathepsin K: The Action in and Beyond Bone.

Rongchen Dai1, Zeting Wu2, Hang Yin Chu1

  • 1Law Sau Fai Institute for Advancing Translational Medicine in Bone & Joint Diseases, Hong Kong Baptist University, Hong Kong, China.

Frontiers in Cell and Developmental Biology
|June 26, 2020
PubMed
Summary

Cathepsin K (CatK) is crucial for bone resorption and a target for osteoporosis drugs. However, inhibiting CatK may cause side effects due to its roles beyond bone.

Keywords:
Cathepsin KCathepsin K inhibitorbone resorptioncardiovascular diseaseslung fibrosisosteoarthritisosteoclastosteoporosis

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Area of Science:

  • Biochemistry
  • Pharmacology
  • Pathology

Background:

  • Cathepsin K (CatK) is a potent lysosomal cysteine protease primarily involved in bone resorption.
  • It is a key target for developing anti-osteoporosis therapies.
  • Current development faces challenges due to potential adverse effects.

Purpose of the Study:

  • To review the functional roles of Cathepsin K (CatK) in both bone and non-bone tissues.
  • To discuss the implications of CatK's extra-skeletal functions on the safety of CatK inhibitors.

Main Methods:

  • Literature review of studies on Cathepsin K (CatK) function.
  • Analysis of clinical trial data for CatK inhibitors, including Odanacatib.
  • Synthesis of information on CatK's roles in various organs and diseases.

Main Results:

  • Cathepsin K (CatK) plays significant roles in bone resorption and is a promising target for osteoporosis.
  • Odanacatib, a selective CatK inhibitor, showed efficacy but was halted due to cardiovascular risks.
  • CatK has diverse functions in multiple organs, suggesting potential off-target effects.

Conclusions:

  • Understanding CatK's non-bone functions is critical for developing safe and effective osteoporosis treatments.
  • Further research is needed to balance therapeutic benefits with potential adverse effects of CatK inhibition.