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Updated: Dec 17, 2025
Switchable Acoustic and Optical Resolution Photoacoustic Microscopy for In Vivo Small-animal Blood Vasculature Imaging
Published on: June 26, 2017
Multiplexed whole-animal imaging with reversibly switchable optoacoustic proteins
Kanuj Mishra1, Mariia Stankevych1, Juan Pablo Fuenzalida-Werner1
1Institute of Biological and Medical Imaging (IBMI), Helmholtz Zentrum München, Neuherberg, Germany.
Abstract:
We introduce two photochromic proteins for cell-specific in vivo optoacoustic (OA) imaging with signal unmixing in the temporal domain. We show highly sensitive, multiplexed visualization of T lymphocytes, bacteria, and tumors in the mouse body and brain. We developed machine learning-based software for commercial imaging systems for temporal unmixed OA imaging, enabling its routine use in life sciences.
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